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Tendon and ligament fibroblast activity: In vitro studies have examined how this compound affects fibroblast behaviour, the cells responsible for producing collagen and extracellular matrix components, making it relevant to connective tissue research

In sum, the safety observations support the concept that the IRR, the target of ARA 290, is induced only by injury, inflammation or metabolic stress and is therefore not generally expressed by normal tissues, thus limiting systemic adverse events

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All of the reasoning above is based on the independent mechanisms of each peptide and the absence of known interactions between their respective pathways